Stochastic Processes and Filtering Theory by Andrew H. JazwinskiGoodreads helps you keep track of books you want to read. Want to Read saving…. Want to Read Currently Reading Read. Other editions. Enlarge cover. Error rating book. Refresh and try again.
Using Stochastic Differential Equations for PK/PD Model Development
Journal of Pharmacokinetics and Pharmacodynamics. The new method has a number of advantages compared to conventional methods. In particular, the new method avoids the exhaustive trial-and-error based search often conducted to determine the most appropriate model structure, because it allows information about the appropriate model structure to be extracted directly from data. This is accomplished through quantification of the uncertainty of the individual parts of an initial model, by means of which tools for performing model diagnostics can be constructed and guidelines for model improvement provided. Furthermore, the new method allows time-variations in key parameters to be tracked and visualized graphically, which allows important functional relationships to be revealed. Using simulated data, the performance of the new method is demonstrated by means of two examples.
PDF | Review of the book with the same title by Andrew H. Jazwinski (New York: Academic, ).
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Table of Contents
Scientific Research An Academic Publisher. ABSTRACT: This paper surveys the field of adaptation mechanism design for uncertainty parameter estimation as it has developed over the last four decades. The adaptation mechanism under consideration generally serves two tightly coupled functions: model identification and change point detection. After a brief introduction, the pa-per discusses the generalized principles of adaptation based both on the engineering and statistical literature. The stochastic multiinput multioutput MIMO system under consideration is mathematically described and the problem statement is given, followed by a definition of the active adaptation principle.