Vitamin C and cancer revisitedThe Micronutrient Information Center has been your open-access resource for evidence-based nutrition information since You can help support our Ph. Vitamin C L-ascorbic acid is a potent reducing agent, meaning that it readily donates electrons to recipient molecules Figure 1. Vitamin C is the primary water-soluble, non-enzymatic antioxidant in plasma and tissues. Even in small amounts, vitamin C can protect indispensable molecules in the body, such as proteins , lipids fats , carbohydrates , and nucleic acids DNA and RNA , from damage by free radicals and reactive oxygen species ROS that are generated during normal metabolism , by active immune cells, and through exposure to toxins and pollutants e. Vitamin C also participates in redox recycling of other important antioxidants; for example, vitamin C is known to regenerate vitamin E from its oxidized form see the article on Vitamin E. The role of vitamin C as a cofactor is also related to its redox potential.
Vitamin C -- Cancer’s Worst Enemy
Vitamin C and cancer revisited
High doses of vitamin C, given every day, without ever stopping, to patients with cancer, as an adjunct to appropriate conventional therapy, improve the general health of nearly every cancer patient, increase survival time somewhat, and have great value for a fortunate few, who respond especially well. Most users should sign in with their email address. If you originally registered with a username please use that to sign in. To purchase short term access, please sign in to your Oxford Academic account above. Don't already have an Oxford Academic account?
winner Linus Pauling. As a result of their studies on patients with. advanced cancer, Cameron and Pauling asserted that high-dose. ascorbic acid can enhance.
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Recent Clinical Studies
This work follows a number of articles by the same group, led by Mark Levine at the National Institute of Diabetes and Digestive and Kidney Diseases, showing that millimolar concentrations of extracellular vitamin C kill cancer cells but not normal cells in a hydrogen peroxide H 2 O 2 -dependent manner 1 — 3. Such millimolar concentrations of vitamin C can be achieved in humans by i. Hence, vitamin C is postulated to exert local pro-oxidant effects in the interstitial fluid surrounding tumor cells, killing them or inhibiting their growth, while leaving normal cells intact 1 — 3. It is well known that vitamin C, or ascorbic acid, is an effective biologic antioxidant and does not act as a pro-oxidant under normal conditions 5 because it does not readily autoxidize, i. In fact, reduction of copper or iron in the catalytic site of certain enzymes underlies ascorbate's well known biologic function as a co-substrate in procollagen, carnitine, and catecholamine biosynthesis 6. Reduced transition metal ions, in contrast to ascorbic acid, readily react with O 2 , reducing it to superoxide radicals Reaction 2 , which in turn dismutate to form H 2 O 2 and O 2 Reaction 3 :.